Weight Loss with Saxenda

Today’s blog post is brought to you by one of our female customers who is struggling to lose extra flab around the belly. Sound familiar?

Well to make matters worse for this lady she has PCOS aka Poly Cystic Ovarian Syndrome. It’s a terrible cluster of issues leading to:

  • irregular periods or none at all
  • pimples
  • hair loss on head/hair overgrowth on arms and body
  • infertility
  • high cholesterol
  • diabetes
  • weight gain

It’s thought to be a genetic problem in the ovaries and its tough as hell to fix.

One of the indirect ways of dealing with PCOS is losing weight which is the focus of today’s blog.

(Other treatment modalities include: metformin, contraceptive pills to rebalance hormones, hormone blockers like clomiphene)

Saxenda is the new kid on the block and is one of three main players. It’s a surprisingly empty field because like anything complex, there is no silver bullet. Diet and exercise help but if you want something more, read on…

Saxenda is a GLP-1 analogue (if you’re a nerd, search it up on Wikipedia) which basically slows down your stomach contents causing you to feel fuller for longer; it also acts at the brain level to alert you to feel that enough is enough; finally, it tells your pancreas to pump more insulin for each meal you have.

It’s an injection done to the thigh, abs or upper-arm ONCE per day (there’s actually another one on the market called Byetta but that’s twice daily with similar results). A pack will set you back $400-500/month (not on the

To be eligible for a script from your GP you have to have a BMI of 30+ (or 27 with diabetes, heart problems, and/or PCOS)

So how long does it take to work? Best results happen at the beginning thankfully…with most of the weight loss during the initial 20 weeks or 5 months. People tend to lose 5-10% of their starting weight.

If you haven’t lost at least 5% by week 12, then chances are it won’t work much further-stop and save your money.

Side effects include nausea and vomiting-50% of people experience this as mild to moderate in severity. In studies people actually have vomited-which ironically for the drug company…is probably a factor in helping with weight loss. Thankfully for us mere mortals it does improve with time. Other side effects can include: irritation, pain, bruising at the injection site. Other things like gall stones and allergies are quite rare.

Risk of pancreatitis (inflammation of pancreas) is very, very rare but hey we don’t know the complete picture because it’s a relatively new drug. There is concern that it may be associated with cancer of the pancreas. Watch this space.

Apart from the weight loss benefits, it also helps to reduce your chances of diabetes by reducing things like your HbA1c  and your sugar spikes after a meal.

I hope this has been informative for our customer and for others like her who are going through PCOS which is a dreadful disease.

As always speak to doc about your personal situation.

Best

xoxo Vien

 

 

4 thoughts on “Weight Loss with Saxenda

  1. Just wondering why people lose the most in 5 months. Do they change their eating habits after that time so it doesn’t work as much? Why would people do it for 12 months if most of the change is in 5 months? Dependent on the answer ‘why’ I guess?

    Like

    • Hi Kim congrats on your journey thus far! If I recall

      correctly you’ve lost 11kgs which is a 10% weight loss!

      well done!

      You asked a great question and unfortunately I haven’t

      find the nitty gritty data to show when and where the

      weight loss happens.

      I can say from a quick look online that most people

      tend to lost about 6-10% of the starting weight and

      this is from trials ranging between 26 weeks to two

      years.

      So it would seem that once one has hit the 10% mark

      that further losses reach a plataeu. So one would want

      to weigh the benefits with the risk of side effects and

      costs.

      Take care, xoxo Vien.

      Here are the data I came across:

      2yr trial

      Completers on liraglutide 2.4/3.0 mg (n=92) maintained

      a 2-year weight loss of 7.8 kg from screening.

      https://www.nature.com/ijo/journal/v36/n6/full/ijo20111

      58a.html

      56 week trial
      From randomization to week 56, weight decreased an

      additional mean 6.2% (s.d. 7.3) with liraglutide and

      0.2% (s.d. 7.0) with placebo
      https://www.nature.com/ijo/journal/v37/n11/abs/ijo20131

      20a.html

      56 week trial

      Baseline weight was 105.7 kg with liraglutide (3.0-mg

      dose), 105.8 kg with liraglutide (1.8-mg dose), and

      106.5 kg with placebo. Weight loss was 6.0% (6.4 kg)

      with liraglutide (3.0-mg dose), 4.7% (5.0 kg) with

      liraglutide (1.8-mg dose), and 2.0% (2.2 kg) with

      placebo

      Weight loss of 5% or greater occurred in 54.3% with

      liraglutide (3.0 mg) and 40.4% with liraglutide (1.8

      mg) vs 21.4% with placebo

      Weight loss greater than 10% occurred in 25.2% with

      liraglutide (3.0 mg) and 15.9% with liraglutide (1.8

      mg) vs 6.7% with placebo
      https://jamanetwork.com/journals/jama/fullarticle/24289

      56

      26 week trial
      weight losses (liraglutide −3·24 kg
      http://www.sciencedirect.com/science/article/pii/S01406

      73609606590

      20 weeks+
      weighted mean difference −2.9 kg,

      http://www.bmj.com/content/344/bmj.d7771.short

      Like

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